WebThe phenolphthiocerol molecules have either 35 or 37 carbon atoms. In most organisms the two hydroxyl groups of both phthiocerols and phenolphthiocerols are esterified by mycocerosic acids . In Mycobacterium marinum and Mycobacterium ulcerans , however, they are esterified by phthioceranic acids [ Daffe88 , Daffe87 ]. WebBiological Unit for 7AKC: monomeric; determined by author and by software (PISA)
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WebThus, the phenolphthiocerol synthase PKS cluster of M. tuberculosis is responsible, in part, for the synthesis of a virulence determinant called phthiocerol dimycocerosate (PDIM). Here, we provide evidence that the PpsE protein, which is part of that cluster, interacts with the type II thioesterase TesA of M. tuberculosis. WebJul 4, 1997 · Surface-exposed unusual lipids containing phthiocerol and phenolphthiocerol are found only in the cell wall of slow-growing pathogenic mycobacteria and are thought … hanson building materials ramsey mn
What is Phenol? Medical Uses, Health Benefits, and Risks
WebSome taxa known to possess this pathway include : Mycobacterium marinum, Mycobacterium tuberculosis H37Rv, Mycobacterium tuberculosis variant bovis Expected Taxonomic Range: Mycobacteriaceae, Nocardiaceae Synonyms: PGL biosynthesis; triglycosyl dimycocerosyl phenolphthiocerol biosynthesis WebDec 1, 2024 · Phthiocerol dimycocerosates (DIM), glycosylated phenolphthiocerol and acid methanolysates are the three characteristic waxes of M.tb. Dimycocerosates of the phthiocerol detected in the free lipids along with glycosylated phenolphthiocerol, also known as phenolglycolipid (PGL), are two important groups of virulence factors in mycobacterial ... WebThe cell wall of Mycobacterium contains various unusual lipids, such as mycolic acid, methyl-branched fatty acids, phthiocerol, and phenolphthiocerol, and these unusual fatty acids are believed to provide resistance to antibacterial agents. Therefore, a better understanding of their biosynthesis pathways should provide novel drug targets. hansonburg mining district